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Clinical Mysteries • Internal Medicine

The Fatigue That Wasn’t Just Overwork

Months of tiredness were blamed on a busy schedule. A careful examination suggested the body was compensating for something else.

A clinical reasoning story for medicos and doctors • Educational composite case

A common complaint

The patient reported low energy, reduced exercise tolerance and occasional palpitations. Work stress and poor sleep seemed sufficient explanations.

The quiet physical clues

Conjunctival pallor and a soft flow murmur prompted a complete blood count. The haemoglobin was substantially reduced.

The twist

Iron-deficiency anaemia was confirmed, and the next question became why iron had been lost—not simply how to replace it.

Take-home message

Fatigue is nonspecific. Examination and a basic differential matter. When iron deficiency is diagnosed, identify the underlying cause rather than repeatedly prescribing iron alone.

Diagnostic principle: do not let the first plausible label stop the search when an important detail does not fit.
Educational note: This is a teaching composite, not a substitute for patient-specific diagnosis or treatment. Real patients require direct clinical assessment and appropriate investigations.